Pulsus Medical

Tools for Precision Medicine Systems

Nexeon was originally founded in 2005 by Mark C. Bates, MD, DSci (Hon), a thought-leader in interventional cardiology and a medical device inventor with more than 50 issued and pending patents. Dr. Bates formed the Company with the goal of changing how innovative ideas in the medical device industry move from concept to reality. Pulsus Medical, LLC has since been formed as a spinout from Nexeon to focus on the ongoing development and commercialization of its proprietary balloon, catheter, and filter technologies used in precision medicine systems.

The company recently completed the phase I FastTrack research plan associated with this proprietary system. The phase II grant was awarded due to successful completion of corresponding phase I milestones, and it funded up to $600,000 of critical preclinical research and process development activities, including the completion of a pre-IDE meeting with the US Food and Drug Administration.

The technology in development under the FastTrack is a nanocomposite-based polymer balloon with microperforations that enables precise, pulse delivery of therapeutic drugs directly at the site of an intravascular lesion. Unlike present-day solutions, which are limited to certain drugs and utilize passive delivery only, this approach is hypothesized to enable more efficient drug delivery directly to the diseased site, reducing the potential for systemic toxicity from downstream drug loss.

In continuation to the above-mentioned development efforts, Nexeon MedSystems and a consortium of strategic partners have recently been awarded an additional € 1.4M to develop the IonCath Drug Delivery System.

The IonCath Drug Delivery System is a drug-coated balloon to reduce restenosis using iontophoresis and electroporation for greater, more effective, active drug delivery.

Patents Related to Pulsus Technologies

The following patents and applications relate to our micro-perforated balloon catheter system for use in the treatment of restenosis associated with hemodialysis.

Nanotube-Reinforced Balloons For Delivering Patents

US 8187221Therapeutic agents within or beyond the wall of blood vessels, and methods of making and using same
JP 5481479Therapeutic agents within or beyond the wall of blood vessels, and methods of making and using same
EP 9771434.9 Therapeutic agents within or beyond the wall of blood vessels, and methods of making and using same

Systems And Methods For Atraumatic Implantation Of Bio-Active Agents Patents

US 7632262Systems and methods for atraumatic implantation of bio-active agents
US 8377032Systems and methods for atraumatic implantation of bio-active agents
EP 9736537.3Systems and methods for atraumatic implantation of bio-active agents
EP 5773060.8Systems and methods for atraumatic implantation of bio-active agents
EP 11150671.3Systems and methods for atraumatic implantation of bio-active agents
AU 2005274775Systems and methods for atraumatic implantation of bio-active agents
JP 4774403Systems and methods for atraumatic implantation of bio-active agents

Apparatus And Methods For Treating Tissue Using Passive Injection Systems Patents

US 7338471Apparatus and methods for treating tissue using passive injection systems
US 7338471Apparatus and methods for treating tissue using passive injection systems
AU 2005274774Apparatus and methods for treating tissue using passive injection systems
JP 4934029Apparatus and methods for treating tissue using passive injection systems
GB & FR 1773440Apparatus and methods for treating tissue using passive injection systems
DE 602005030269.7Apparatus and methods for treating tissue using passive injection systems

Implantable Device For Treating Disease States And Methods Of Using Same Patents

US 7651696Implantable device for treating disease states and methods of using same

Methods And Apparatus For Treating Infarcted Regions Of Tissue Following Patents

US 7819856Acute myocardial infarction
US 8062283Acute myocardial infarction

Apparatus For The Delivery Of Drugs Or Gene Therapy Patents

US 7648495Into a patient’s vasculature and methods of use